Structural characterisation of SARM in axon degeneration and cell death
نویسندگان
چکیده
منابع مشابه
dSarm / Sarm 1 Is Required for Activation of an Injury - Induced Axon Death Pathway
Immun. 65, 2396 (1997). 7. N. H. Salzman, D. Ghosh, K. M. Huttner, Y. Paterson, C. L. Bevins, Nature 422, 522 (2003). 8. B. Ericksen, Z. Wu, W. Lu, R. I. Lehrer, Antimicrob. Agents Chemother. 49, 269 (2005). 9. N. H. Salzman et al., Nat. Immunol. 11, 76 (2010). 10. See supplementary materials on Science Online. 11. A. J. Bäumler, R. M. Tsolis, P. J. Valentine, T. A. Ficht, F. Heffron, Infect. I...
متن کاملAxon degeneration: Mechanisms and implications of a distinct program from cell death.
Axon degeneration has been proposed to be a new therapeutic target for neurodegenerative diseases, because it usually occurs earlier than neuronal cell body death with a distinct active program from apoptosis and necrosis. Overexpression of Wld(S) or Nmnats (nicotinamide mononucleotide adenylytransferase, EC2.7.7.1) has been demonstrated to delay axon degeneration initiated by various insults. ...
متن کاملSarm1-mediated axon degeneration requires both SAM and TIR interactions.
Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a wide range of neurological disorders. In an RNAi-based screen performed in cultured mouse DRG neurons, we observed strong suppression of injury-induced axon degeneration upon knockdown of Sarm1 [SARM (sterile α-motif-containi...
متن کاملGuidance molecules in axon pruning and cell death.
Axon pruning and neuronal cell death constitute two major regressive events that enable the establishment of fully mature brain architecture and connectivity. Although the cellular mechanisms for these two events are thought to be distinct, recent evidence has indicated the direct involvement of axon guidance molecules, including semaphorins, netrins, and ephrins, in controlling both processes....
متن کاملStructural Characterisation of a Polysaccharide from Radix Ranunculus ternati
A water soluble polysaccharide, HB-1, with a molecular weight of 23,930, was isolated from radix Ranunculi ternati. by hot water extraction, ethanol precipitation, deproteination,ultrafiltration and gel-filtration column chromatography. Its sugar composition was determined by GLC as Glc, Ara, and Gal in a molar ration of 16.071: 2.722: 1. And the absolute configuration of Glc was identified as ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2017
ISSN: 2053-2733
DOI: 10.1107/s205327331708740x